Scientific studies (CBD)

For CBD, recent scientific studies highlight its potential benefits for relieving menstrual pain. CBD, a non-psychoactive compound extracted from cannabis, is known for its anti-inflammatory and analgesic properties. Research indicates that CBD may help reduce menstrual cramps, back pain, and other symptoms associated with menstruation. Thanks to its muscle-relaxing effects and ability to reduce inflammation, CBD is emerging as a promising natural alternative for those looking to relieve menstrual pain without the side effects of traditional medications.

📄 CBD & Endometriosis

Translation of the scientific study: "Molecular and biochemical mechanism of cannabidiol in the management of inflammatory and oxidative processes associated with endometriosis"

Okten SB, Cetin C, Tok OE, Guler EM, Taha SH, Ozcan P, Ficicioglu C.

Reprod Biomed Online. 2023 May;46(5):865-875. doi: 10.1016/j.rbmo.2023.01.018. Epub 2023 Feb 2 / PMID: 36997400"

“Endometriosis is commonly associated with inflammation and chronic pelvic pain.

This article focuses on the anti-inflammatory, antioxidant, and analgesic effects of cannabidiol (CBD) and its potential role in endometriosis.

CBD administration significantly reduced the diameter, volume, and surface area of ​​the lesions.
Study Conclusions: CBD showed an ability to modify lesion morphology by reducing epithelial glands and stroma. It also demonstrated antioxidant effects, decreasing lipid peroxidation and the expression of Nox-1 and Nox-4 enzymes. CBD restored the oxidative balance of endogenous cellular defense, as evidenced by SOD activity and GSH levels in lesions. In addition, CBD revealed significant antifibrotic effects, illustrated by Masson's trichrome staining and decreased expression of MMP-9, iNOS, and TGF-β. Furthermore, CBD reduced inflammation both in the sampled lesions, as shown by increased Ikb-α and decreased cytosolic expressions of COX2 as well as reduced nuclear localization of NFkB, and in peritoneal fluids, as revealed by reduced levels of TNF-α, PGE2 and IL-1α. Finally, CBD has significant analgesic effects, as shown by decreased recruitment of mast cells in the spinal cord and reduced release of neurosensitizing and pro-inflammatory mediators.

Decryption: CBD has several beneficial effects on the body. It helps modify and reduce certain lesions, has antioxidant properties, and restores the balance of cellular natural defenses. CBD also decreases the formation of scar tissue and reduces inflammation. In addition, it has analgesic effects, which means it can relieve pain by reducing the presence of certain cells and substances responsible for pain and inflammation.

In conclusion, the data collected showed that CBD has effective and coordinated effects in suppressing endometriosis."

📄 CBD & Menstrual Pain

Translation of the scientific study: "Medical cannabis for gynecological pain: A systematic review", Liang AL, Gingher EL, Coleman JS.

Obstet Gynecol. 2022 Feb 1;139(2):287-296. doi: 10.1097/AOG.0000000000004656. / PMID: 3510406

"Objective: The endocannabinoid system plays a role in pain perception and inflammation. Cannabis contains delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), cannabinoids that bind to receptors in this system. A fatty acid called palmitoylethanolamide (PEA) enhances the effects of endogenous cannabinoids. Given its increasing use, we wanted to examine the patterns of cannabis use for gynecological pain and its effectiveness as an analgesic.
Study Conclusion: Survey data show that the majority of women reported that cannabis improves pain related to various gynecological conditions. Cohort studies and a randomized controlled trial with medications combined with PEA have reported pain reduction. However, interpretation of the results is limited by the diversity of formulations, administration methods, and dosages, which precludes a definitive conclusion on the efficacy of cannabis for gynecological pain relief.

📄 CBD & Administration by Patch

Translation of the scientific study: "Cannabinoid delivery systems for the treatment of pain and inflammation" Natascia Bruni,Carlo Della Pepa, Simonetta Oliaro-Bosso, Enrica Pessione, Daniela Gastaldi, Franco Dosio

Publication: 2018 Sep 27.doi: 10.3390/molecules23102478 / PMCID:PMC6222489 / PMID:30262735

“Transdermal delivery allows CBD to be delivered through the skin via patches or other delivery systems. While comparable to oral forms in terms of efficacy, transdermal patches offer numerous advantages. Transdermal delivery avoids the first-pass effect associated with the oral route, thus improving bioavailability. In addition, it allows for steady infusion over an extended period, while minimizing the adverse effects of high concentrations. Topical delivery is potentially ideal for localized symptoms, such as those seen in dermatological conditions and arthritis, but also for peripheral neuropathic pain.

In conclusion, using transdermal patches to administer CBD has many advantages over oral forms."

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